Understanding how a specific receptor affects gum disease and bone loss
Official title: Mechanisms of peroxisome proliferator-activated receptor-alpha regulation in peridontitis
Funded at Ada Forsyth Institute, INC. · NIH-10915090 · Data updated 2026-11-12
This study is looking at how a specific protein in your body might help reduce inflammation and bone loss in gum disease, which could lead to new treatments that improve your gum health and protect your bones.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 8, 2023 |
| Project end | September 7, 2025 |
| Funding year | 2023 |
| Award (this year) | $497,500 |
| NIH project number | 1R56DE032325-01A1 |
| Project ID | NIH-10915090 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from periodontal disease or those at risk of developing it.
✕Less likely to help
Patients without periodontal disease or those with conditions unrelated to gum health may not benefit from this research.
What this research studies
This research investigates the role of peroxisome proliferator-activated receptor-alpha (PPARα) in periodontal disease, focusing on its impact on inflammation and bone resorption. The study aims to understand how activating PPARα can reduce inflammation and bone loss associated with periodontitis by examining its effects on immune cells and signaling pathways. Patients may benefit from insights into new treatments that target this receptor to improve gum health and prevent bone damage. The research involves laboratory experiments using gingival cells and animal models to explore these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing periodontal disease and preventing associated bone loss.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for treating inflammatory conditions, suggesting potential for success in this area.
Where this research is happening
-
Ada Forsyth Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Hu, Yang — Ada Forsyth Institute, INC.
- Study coordinator: Hu, Yang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.