Understanding how a specific receptor affects echovirus infections
The Role of FcRn in Echovirus Entry and Pathogenesis
This study is looking at how a specific protein in our bodies helps echoviruses get into cells and cause illness, and it's for anyone interested in understanding how these viruses affect our intestines and liver, with hopes of finding new ways to prevent infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10764297 on NIH RePORTER |
What this research studies
This research investigates the role of the neonatal Fc receptor (FcRn) in how echoviruses enter and cause disease in the body. By using gene editing techniques, the researchers have found that modifying FcRn can reduce echovirus infections in cells. They are also exploring how FcRn interacts with echoviral particles to enhance their attachment to cells, which could lead to new insights into echovirus pathogenesis. The study aims to provide a deeper understanding of how echoviruses affect different cell types, particularly in the intestines and liver.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for echovirus infections, particularly those with compromised immune systems or underlying health conditions.
Not a fit: Patients who are not affected by echovirus infections or do not have related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating echovirus infections.
How similar studies have performed: Previous research has shown promising results in understanding viral entry mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Coyne, Carolyn B — Duke University
- Study coordinator: Coyne, Carolyn B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.