Understanding how a specific receptor affects chronic pain and inflammation
Lymphotoxin-Beta Receptor Peripheral Signaling Regulates the Transition to Inflammation and Neuropathy-Induced Chronic Pain
This study is looking at how a specific receptor in the body might help us understand and manage chronic pain and inflammation, especially after injuries, to find better ways to treat pain without relying on opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10819152 on NIH RePORTER |
What this research studies
This research investigates the role of the lymphotoxin-beta receptor in regulating chronic pain and inflammation, particularly after tissue or nerve damage. It aims to uncover the mechanisms that lead to the transition from acute to chronic pain, which is often exacerbated by opioid misuse. By studying this receptor's signaling pathways, the research seeks to identify potential targets for new pain management strategies that could reduce reliance on opioids. The approach involves using models of inflammatory and chemotherapy-induced peripheral neuropathy to explore these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic pain conditions, particularly those related to inflammation or chemotherapy-induced neuropathy.
Not a fit: Patients with acute pain conditions or those not experiencing chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain that minimize the need for opioids and reduce associated health risks.
How similar studies have performed: Previous research has shown promise in understanding the role of immune responses in chronic pain, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Akopian, Armen N — University of Texas Hlth Science Center
- Study coordinator: Akopian, Armen N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.