Understanding how a specific receptor affects cell signaling in diseases like cancer
Official title: Regulation of chemokine receptor signaling
Funded at Medical College of Wisconsin · NIH-10912434 · Data updated 2026-11-12
This study is looking at how a specific protein called CXCR4 works in our bodies, especially how it affects things like development, immune responses, and cancer, to help find better ways to treat diseases linked to this protein.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $507,000 |
| NIH project number | 5R35GM149253-02 |
| Project ID | NIH-10912434 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that exhibit high levels of CXCR4 expression or those with conditions related to immune function and embryogenesis.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling or those not expressing CXCR4 may not benefit from this research.
What this research studies
This research investigates the mechanisms of G protein-coupled receptor (GPCR) signaling, focusing on the C-X-C chemokine receptor 4 (CXCR4), which plays a crucial role in various physiological processes and is linked to several diseases, including cancer. By using cell culture models and advanced imaging techniques, the study aims to uncover how CXCR4 signaling influences embryogenesis, immune function, and cancer progression. The research will explore the interactions of CXCR4 with other proteins and the biophysical factors that regulate its signaling pathways. This could lead to a better understanding of how to target CXCR4 in therapeutic settings.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers associated with CXCR4 signaling.
How similar studies have gone: Previous research has shown promising results in targeting GPCR signaling pathways, indicating potential for success in this area.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Marchese, Adriano — Medical College of Wisconsin
- Study coordinator: Marchese, Adriano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.