Understanding how a specific receptor affects cell signaling in diseases like cancer
Regulation of chemokine receptor signaling
This study is looking at how a specific protein called CXCR4 works in our bodies, especially how it affects things like development, immune responses, and cancer, to help find better ways to treat diseases linked to this protein.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10912434 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of G protein-coupled receptor (GPCR) signaling, focusing on the C-X-C chemokine receptor 4 (CXCR4), which plays a crucial role in various physiological processes and is linked to several diseases, including cancer. By using cell culture models and advanced imaging techniques, the study aims to uncover how CXCR4 signaling influences embryogenesis, immune function, and cancer progression. The research will explore the interactions of CXCR4 with other proteins and the biophysical factors that regulate its signaling pathways. This could lead to a better understanding of how to target CXCR4 in therapeutic settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that exhibit high levels of CXCR4 expression or those with conditions related to immune function and embryogenesis.
Not a fit: Patients with conditions unrelated to GPCR signaling or those not expressing CXCR4 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers associated with CXCR4 signaling.
How similar studies have performed: Previous research has shown promising results in targeting GPCR signaling pathways, indicating potential for success in this area.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Marchese, Adriano — Medical College of Wisconsin
- Study coordinator: Marchese, Adriano
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.