Understanding how a specific receptor affects cell signaling and diseases.
Official title: Regulation of chemokine receptor signaling
Funded at Medical College of Wisconsin · NIH-11098173 · Data updated 2026-11-12
This study is looking at how a specific protein called CXCR4 works in our bodies, especially in relation to cancer, to help us understand it better and find new ways to treat related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $39,724 |
| NIH project number | 3R35GM149253-02S1 |
| Project ID | NIH-11098173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that exhibit aberrant CXCR4 expression or those interested in the underlying mechanisms of GPCR signaling.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling or CXCR4 expression may not benefit from this research.
What this research studies
This research investigates the mechanisms of G protein-coupled receptor (GPCR) signaling, focusing on the C-X-C chemokine receptor 4 (CXCR4), which plays a crucial role in various physiological processes and is linked to several diseases, including cancer. By using cell culture models and advanced imaging techniques, the research aims to uncover the biophysical and structural factors that influence GPCR signaling and the roles of specific proteins in regulating this process. Patients may benefit from a deeper understanding of how CXCR4 contributes to cancer progression and other conditions, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers associated with CXCR4 signaling.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling, indicating that this approach could yield valuable insights.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Marchese, Adriano — Medical College of Wisconsin
- Study coordinator: Marchese, Adriano
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.