Understanding how a specific receptor affects blood vessel changes in high blood pressure.
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertension
This study is looking at how a specific receptor in your blood vessels affects changes related to high blood pressure, with the hope of finding new ways to help manage hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11005019 on NIH RePORTER |
What this research studies
This research investigates the role of the formyl peptide receptor (FPR-1) in the remodeling of blood vessels associated with hypertension. By examining how this receptor influences actin polymerization and the movement of immune cells in arteries, the study aims to uncover the mechanisms behind vascular changes in high blood pressure. The approach includes analyzing the receptor's activation and its effects on arterial structure and function, which could lead to new treatment strategies for hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with hypertension who may benefit from new therapeutic approaches.
Not a fit: Patients without hypertension or those with other unrelated vascular conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for hypertension by targeting the mechanisms of vascular remodeling.
How similar studies have performed: Previous research has shown that targeting immune mechanisms can be effective in managing hypertension, suggesting that this approach may yield promising results.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Wenceslau, Camilla Ferreira — University of South Carolina at Columbia
- Study coordinator: Wenceslau, Camilla Ferreira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.