Understanding how a specific proton channel regulates pH in cells
Regulation of Voltage-gated Proton Channel
This study is looking at a special channel in cells that helps keep the right balance of acidity, which is important for immune cells and sperm, to see how it works with other proteins and how it might help with health issues related to pH balance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11012414 on NIH RePORTER |
What this research studies
This research investigates the Hv1 proton channel, which is crucial for maintaining pH balance in various cell types, including immune cells and sperm. By examining how this channel interacts with specific transmembrane proteins, the study aims to uncover its role in acid extrusion and the production of reactive oxygen species. The research employs biophysical techniques to analyze the channel's activity and its effects on cellular functions, which could have implications for conditions related to pH imbalance. Patients may benefit from insights gained about how to modulate this channel's activity for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with conditions affecting immune function or pH regulation.
Not a fit: Patients with unrelated conditions that do not involve pH regulation or immune response may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to pH imbalance and immune response.
How similar studies have performed: Previous research has shown promising results in understanding the role of ion channels in cellular functions, suggesting potential for success in this area.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Hong, Liang — University of Illinois at Chicago
- Study coordinator: Hong, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.