Understanding how a specific protein regulates sleep and metabolism
Mechanism of Sleep Regulation by SIK3
This study is looking at how a specific protein called SIK3 affects sleep and its links to metabolic issues, using tiny worms to help understand how our genes and body processes influence our sleep, with the hope of finding ways to improve both sleep and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11121790 on NIH RePORTER |
What this research studies
This research investigates the role of the salt inducible kinase SIK3 in regulating sleep and its connection to metabolic disorders. By studying the interactions between neurons and metabolic processes, the research aims to uncover how sleep drive is influenced by specific genetic and biochemical pathways. The project will utilize various experimental approaches, including genetic manipulation in model organisms like C. elegans, to explore the mechanisms behind sleep regulation. Ultimately, the goal is to identify potential targets for improving sleep and metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing sleep disorders or metabolic issues, particularly those with comorbid conditions.
Not a fit: Patients with isolated sleep disorders or metabolic conditions that do not involve the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sleep and metabolic disorders, improving overall health and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding the connections between sleep and metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Raizen, David Menassah — University of Pennsylvania
- Study coordinator: Raizen, David Menassah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.