Understanding how a specific protein regulates gene expression
Dissecting the Mechanisms of Quaking-Regulated RNA Processing
['FUNDING_OTHER'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-11087692
This study is looking at a protein called QKI5 that helps control how genes work, and it aims to find out how this protein could be used to develop new treatments for heart disease and cancer, which could help patients in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-11087692 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Quaking-5 isoform (QKI5), a protein that binds RNA, in regulating gene expression. The team will explore how QKI5 is controlled, how it performs its regulatory functions, and the effects of these actions on gene expression. By filling knowledge gaps about QKI5, the research aims to uncover its potential as a target for RNA-based therapies, particularly in conditions like heart disease and cancer. Patients may benefit from insights gained into how gene expression is regulated in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by heart diseases, cancers, or other conditions linked to dysregulated gene expression.
Not a fit: Patients with conditions unrelated to gene expression regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new RNA-based therapies for diseases like heart disease and cancer.
How similar studies have performed: Other research has shown promise in targeting RNA binding proteins for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAGG, WILLIAM SAMUEL — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: FAGG, WILLIAM SAMUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiac Diseases, Cardiac Disorders