Understanding how a specific protein regulates gene expression
Official title: Dissecting the Mechanisms of Quaking-Regulated RNA Processing
Funded at University of Texas Med Br Galveston · NIH-11087692 · Data updated 2026-11-12
This study is looking at a protein called QKI5 that helps control how genes work, and it aims to find out how this protein could be used to develop new treatments for heart disease and cancer, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $400,000 |
| NIH project number | 5R35GM151324-03 |
| Project ID | NIH-11087692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by heart diseases, cancers, or other conditions linked to dysregulated gene expression.
✕Less likely to help
Patients with conditions unrelated to gene expression regulation may not benefit from this research.
What this research studies
This research investigates the role of the Quaking-5 isoform (QKI5), a protein that binds RNA, in regulating gene expression. The team will explore how QKI5 is controlled, how it performs its regulatory functions, and the effects of these actions on gene expression. By filling knowledge gaps about QKI5, the research aims to uncover its potential as a target for RNA-based therapies, particularly in conditions like heart disease and cancer. Patients may benefit from insights gained into how gene expression is regulated in various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new RNA-based therapies for diseases like heart disease and cancer.
How similar studies have gone: Other research has shown promise in targeting RNA binding proteins for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Fagg, William Samuel — University of Texas Med Br Galveston
- Study coordinator: Fagg, William Samuel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.