Understanding how a specific protein regulates egg cell development and fertility
Official title: Novel approaches for the discovery of dephosphorylation control in oocyte meiosis
Funded at University of Southern Mississippi · NIH-10918296 · Data updated 2026-11-12
This study is looking at how a protein called PP1 helps with the development of egg cells and female fertility, which could explain why some women have trouble getting pregnant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern Mississippi NIH-funded |
| Lab location | 1 site (Hattiesburg, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $228,041 |
| NIH project number | 5R00HD103909-03 |
| Project ID | NIH-10918296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility or subfertility due to meiotic failures.
✕Less likely to help
Patients who are not experiencing fertility issues or those with infertility due to non-meiotic factors may not benefit from this research.
What this research studies
This research investigates the role of a protein called PP1 in the regulation of meiosis, which is crucial for egg cell development and female fertility. By focusing on how PP1 interacts with other proteins, the study aims to uncover the molecular mechanisms that lead to successful embryo development. The researchers will use innovative techniques to manipulate PP1 activity in oocytes, which may help clarify its essential functions during meiosis. This could provide insights into why some women experience difficulties in conceiving due to meiotic failures.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing female infertility and improving assisted reproductive technologies.
How similar studies have gone: While the specific approach of targeting PP1 in oocytes is novel, previous research has shown that understanding protein interactions can lead to breakthroughs in fertility treatments.
Where this research is happening
-
University of Southern Mississippi
Hattiesburg, United States Active
Researchers
- Principal investigator: Camlin, Nicole Jacqueline — University of Southern Mississippi
- Study coordinator: Camlin, Nicole Jacqueline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.