Understanding how a specific protein pathway affects DNA replication and repair
Investigating the roles of the H3.1-TSK/TONSL pathway during chromatin replication
This study is looking at a specific pathway in our cells that helps copy our DNA, which could help us understand how mistakes happen that lead to diseases like cancer and brain disorders, with the hope of finding new ways to keep our genes healthy and prevent these illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10918047 on NIH RePORTER |
What this research studies
This research investigates the H3.1-TSK/TONSL pathway, which plays a crucial role in the replication of chromatin, the material that makes up our DNA. By studying how this pathway influences the copying of genetic and epigenetic information, the research aims to uncover mechanisms that could lead to mutations associated with diseases like cancer and neurodegenerative disorders. The team will explore how histone variants and modifications are involved in DNA repair and replication processes, potentially revealing new targets for therapeutic intervention. Patients may benefit from insights gained about how to maintain genomic stability and prevent disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with cancers or neurodegenerative disorders linked to genetic and epigenetic mutations.
Not a fit: Patients with conditions unrelated to genetic or epigenetic mutations may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers and neurodegenerative disorders by enhancing our understanding of DNA replication and repair mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding the roles of epigenetic mechanisms in DNA repair, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Jacob, Yannick — Yale University
- Study coordinator: Jacob, Yannick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.