Understanding how a specific protein pathway affects breast cancer growth
Function and Mechanism of the Hippo-PI5P4K Axis for Growth Control
This study is looking at how a specific protein pathway affects cell growth in breast cancer, hoping to find new ways to treat the disease by understanding what happens when this pathway doesn't work properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10874659 on NIH RePORTER |
What this research studies
This research investigates the role of a protein pathway known as the Hippo-PI5P4K axis in regulating cell growth, particularly in the context of breast cancer. The team aims to uncover how this pathway is involved in maintaining cellular balance and how its dysfunction may lead to tumor development. By using advanced laboratory techniques, they will explore the interactions between various proteins and their effects on cancer cell growth. This could provide insights into new therapeutic targets for breast cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer who may benefit from novel treatment approaches targeting the Hippo-PI5P4K pathway.
Not a fit: Patients with non-breast cancer types or those whose tumors do not involve the Hippo-PI5P4K signaling pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating breast cancer by targeting the mechanisms that control tumor growth.
How similar studies have performed: While the specific focus on the Hippo-PI5P4K axis is relatively novel, previous research has shown success in targeting similar signaling pathways in cancer treatment.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Emerling, Brooke M — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Emerling, Brooke M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.