Understanding how a specific protein modification affects tooth enamel formation
Essential role of amelogenin phosphorylation in tooth enamel formation
This study is looking at how a specific change in a protein important for tooth enamel affects the strength and quality of enamel, which is essential for keeping your teeth healthy, using a special mouse model to help understand any problems that might lead to dental issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10907709 on NIH RePORTER |
What this research studies
This research investigates the role of phosphorylation in amelogenin, a key protein in tooth enamel formation. By using a specialized mouse model, researchers are examining how changes in this protein affect the structure and quality of enamel. The study focuses on the impact of a specific amino acid modification on the development of enamel, which is crucial for dental health. Through detailed analysis of enamel tissues, the research aims to uncover the mechanisms behind enamel defects and their implications for dental diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of dental enamel defects or susceptibility to dental caries.
Not a fit: Patients with no dental enamel issues or those who have already undergone significant dental treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of dental enamel defects, potentially reducing the incidence of dental caries.
How similar studies have performed: Previous research has shown promising results in understanding protein modifications in dental health, indicating that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Beniash, Elia — University of Pittsburgh at Pittsburgh
- Study coordinator: Beniash, Elia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.