Understanding how a specific protein modification affects cancer suppression.
Regulation of pten tumor suppressive functions by C-tail phosphorylation.
This study is looking at how a protein called Pten helps stop cancer and how a special change to it might affect its job, using mice to learn more about how this could help create better treatments for people with certain types of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10893351 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called Pten, which is crucial for preventing cancer, and how its function is influenced by a specific modification known as C-tail phosphorylation. By using mouse models, the researchers aim to manipulate Pten to better understand its behavior and interactions in the body. The goal is to uncover how changes in Pten can lead to cancer and to develop new treatment strategies for patients with cancers that involve Pten alterations.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced cancers that have alterations in the Pten gene.
Not a fit: Patients with cancers not associated with Pten alterations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for patients with advanced cancers linked to Pten dysfunction.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Baker, Darren — Mayo Clinic Rochester
- Study coordinator: Baker, Darren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.