Understanding how a specific protein interacts to maintain genome stability
Insight into the mechanism of action of the SSB interactome
This study is looking at a special protein that helps keep our DNA safe and how it works with other proteins, which could help us understand genetic changes linked to cancer, especially for people with BRCA2 gene mutations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11066441 on NIH RePORTER |
What this research studies
This research investigates the single-stranded DNA binding protein (SSB) and its interactions with other proteins that are crucial for maintaining genome integrity. By exploring the mechanisms of action of the SSB interactome, the study aims to fill a significant gap in our understanding of how these proteins function together. The research employs advanced techniques such as cryo-electron microscopy to visualize these interactions at a molecular level. This knowledge could lead to insights into the genetic mutations associated with cancer, particularly those involving the BRCA2 gene.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast cancer or known mutations in the BRCA2 gene.
Not a fit: Patients without genetic predispositions to breast cancer or those not affected by genome stability issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for cancers associated with BRCA2 mutations.
How similar studies have performed: Other research has shown success in understanding protein interactions related to genome stability, making this approach promising.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Bianco, Piero R — University of Nebraska Medical Center
- Study coordinator: Bianco, Piero R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.