Understanding how a specific protein interaction affects tuberculosis
The Rv2623-Rv1747 interaction: regulation of the in vivo fate of M. tuberculosis
This study is looking at how two proteins in the tuberculosis bacteria work together and how that affects the bacteria's ability to survive and cause illness, which could help us find better ways to treat or prevent tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10749886 on NIH RePORTER |
What this research studies
This research investigates the interaction between two proteins, Rv2623 and Rv1747, in Mycobacterium tuberculosis (Mtb) to understand how they influence the bacterium's life cycle and its ability to cause disease. By studying these interactions, the research aims to uncover the mechanisms that allow Mtb to persist in the host and potentially reactivate after a latent phase. The approach includes using animal models to observe the effects of manipulating these proteins on the growth and behavior of the bacteria. This could lead to new insights into tuberculosis pathogenesis and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are infected with Mycobacterium tuberculosis, especially those with latent tuberculosis.
Not a fit: Patients who are not infected with Mycobacterium tuberculosis or those with active tuberculosis who are already receiving treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tuberculosis, particularly for those with latent infections.
How similar studies have performed: Other research has shown success in understanding bacterial interactions and their implications for disease, making this approach promising yet still exploring novel aspects.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Chan, John R. — Rutgers Biomedical and Health Sciences
- Study coordinator: Chan, John R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.