Understanding how a specific protein influences nerve cell connections in the brain
Official title: The role of extracellular matrix in axon routing
Funded at Upstate Medical University · NIH-10929442 · Data updated 2026-11-12
This study is looking at how a protein called β2 laminin helps nerve cells in the brain grow and connect properly, especially in the area that processes what we see, which could lead to better understanding and treatments for vision-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $407,500 |
| NIH project number | 5R01EY034653-02 |
| Project ID | NIH-10929442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with visual processing disorders or conditions affecting nerve cell growth.
✕Less likely to help
Patients with unrelated neurological conditions or those not experiencing visual processing issues may not receive any benefit from this research.
What this research studies
This research investigates the role of a protein called β2 laminin in guiding the growth of nerve cell axons in the brain, particularly at the optic chiasm where visual signals are processed. By examining how this protein affects the behavior of radial glial cells and midline neurons, the study aims to uncover the mechanisms that ensure proper nerve connections for vision. The research involves a series of experiments to observe changes in axon growth and guidance cues when β2 laminin is present or absent. Patients may benefit from insights gained about visual processing and potential treatments for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating vision-related disorders by enhancing our understanding of nerve cell connections.
How similar studies have gone: Previous research has shown that understanding the role of extracellular matrix proteins in nerve cell guidance can lead to significant advancements in treating neurological conditions.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Martínez-De Luna, Reyna I — Upstate Medical University
- Study coordinator: Martínez-De Luna, Reyna I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.