Understanding how a specific protein in fat cells affects metabolism and insulin resistance
Official title: Elucidating the roles of adipocyte KAT8 in lipoatrophy and systemic insulin resistance
Funded at Lsu Pennington Biomedical Research Ctr · NIH-10980818 · Data updated 2026-11-12
This study is looking at a protein called KAT8 in fat cells to see how it affects metabolic health and insulin sensitivity, which could help us understand and manage conditions like obesity and Type 2 diabetes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $450,000 |
| NIH project number | 1R01DK135266-01A1 |
| Project ID | NIH-10980818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals over 21 years old who are experiencing metabolic issues related to obesity or insulin resistance.
✕Less likely to help
Patients who are under 21 years old or do not have metabolic disorders related to adipocyte function may not benefit from this research.
What this research studies
This research investigates the role of KAT8, a protein found in fat cells, in relation to metabolic health and insulin sensitivity. By studying how KAT8 functions in adipocytes, the research aims to uncover its impact on conditions like obesity and Type 2 diabetes. The approach includes analyzing adipocyte biology and its contributions to systemic metabolic health, which could lead to new insights into managing metabolic disorders. Patients may be involved in studies that explore the genetic and functional aspects of KAT8 in relation to their metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating obesity-related metabolic disorders.
How similar studies have gone: Previous research has shown that understanding adipocyte biology can lead to significant advancements in treating metabolic diseases, suggesting that this approach has potential for success.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Stephens, Jacqueline M — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Stephens, Jacqueline M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.