Understanding how a specific protein in Chlamydia affects its growth and development
Official title: Characterizing the Function of the Periplasmic Protease Tsp in Chlamydial Secondary Differentiation
Funded at University of Nebraska Medical Center · NIH-10792639 · Data updated 2026-11-12
This study is looking at a specific protein in Chlamydia to see how it helps the bacteria grow and change inside our bodies, which could lead to new ways to understand and treat infections caused by this germ.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | February 21, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $188,875 |
| NIH project number | 5R21AI171228-02 |
| Project ID | NIH-10792639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be at risk for Chlamydia infections or related complications.
✕Less likely to help
Patients who are not at risk for Chlamydia infections or those who have already been effectively treated for such infections may not benefit from this research.
What this research studies
This research investigates the role of the periplasmic protease Tsp in the life cycle of Chlamydia, a bacterium responsible for various serious infections, including sexually transmitted infections and preventable blindness. By examining how this protein influences Chlamydia's ability to differentiate and adapt within host cells, the study aims to uncover new insights into the pathogen's biology. The approach involves detailed biological and cellular analyses to understand the mechanisms behind Chlamydia's development and its interactions with human cells.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for diagnosing and treating Chlamydia infections, potentially reducing the incidence of related diseases.
How similar studies have gone: While research on Chlamydia has been extensive, the specific focus on the Tsp protease is relatively novel, suggesting potential for new discoveries.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Ouellette, Scot P — University of Nebraska Medical Center
- Study coordinator: Ouellette, Scot P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.