Understanding how a specific protein in brain cells affects Alzheimer's disease progression
Official title: Investigating the role of astrocyte specific NFIA during initiation and progression of AD pathogenesis
Funded at Baylor College of Medicine · NIH-10897026 · Data updated 2026-11-12
This study is looking at a protein called NFIA in brain cells to see how it might influence the development of Alzheimer's disease, and it's for anyone interested in understanding more about how changes in this protein could affect memory and brain health in people with Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $102,308 |
| NIH project number | 5K01AG083128-02 |
| Project ID | NIH-10897026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of NFIA, a protein found in astrocytes (a type of brain cell), in the development and progression of Alzheimer's disease (AD). By using a newly developed animal model, the researchers will explore how changes in NFIA levels affect brain function and memory, as well as the accumulation of harmful proteins associated with AD. The study aims to confirm NFIA's expression in human brains affected by AD and analyze its impact on brain health over time. This research could provide insights into potential therapeutic targets for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of astrocytes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Choi, Dongjoo — Baylor College of Medicine
- Study coordinator: Choi, Dongjoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.