Understanding how a specific protein in bacteria affects gum disease
Official title: Investigating the Function of Fimbriae-forming Lipoprotein in Porphyromonas gingivalis
Funded at Ada Forsyth Institute, INC. · NIH-10939177 · Data updated 2026-11-12
This study is looking at a protein called PG1881 to see how it affects the movement and clustering of a bacteria linked to gum disease, which could help us find new ways to treat gum problems for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | December 1, 2023 |
| Project end | December 2, 2024 |
| Funding year | 2025 |
| Award (this year) | $13,365 |
| NIH project number | 5F31DE033227-02 |
| Project ID | NIH-10939177 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing periodontal disease or those at risk due to bacterial infections.
✕Less likely to help
Patients without periodontal disease or those who do not have a significant bacterial infection may not benefit from this research.
What this research studies
This research investigates the role of a protein called PG1881 in the behavior of Porphyromonas gingivalis, a bacterium linked to gum disease. The study focuses on how this protein influences the bacterium's ability to move and form biofilms, which are clusters of bacteria that can lead to tissue damage and tooth loss. By analyzing genetic and protein interactions, the research aims to uncover the mechanisms behind bacterial migration and its impact on periodontal health. Patients may benefit from insights that could lead to new treatments for gum disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal disease, potentially reducing tooth loss and improving oral health.
How similar studies have gone: Previous research has shown that understanding bacterial behavior and protein functions can lead to significant advancements in treating infections, suggesting this approach has potential for success.
Where this research is happening
-
Ada Forsyth Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Rothenberger, Christina — Ada Forsyth Institute, INC.
- Study coordinator: Rothenberger, Christina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.