Understanding how a specific protein helps transport drugs and metabolites in the body
Equipment Supplement NOT-GM-24-021
This study is looking at a special protein called SLC22A24 that helps our cells manage different substances, including medications, to see how it works with certain compounds, which could help doctors find better ways to use drugs in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11037661 on NIH RePORTER |
What this research studies
This research investigates the SLC22A24 membrane transporter, which is part of a larger family of proteins that help cells take up and remove various substances, including drugs and metabolites. The study aims to identify the specific roles of SLC22A24 in processing steroid glucuronides and other compounds, using advanced techniques such as cell line studies and isotopic uptake assays. By understanding how this transporter functions, researchers hope to uncover new insights into drug disposition and metabolism, which could lead to improved therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are taking medications that may be affected by the SLC22A24 transporter or those with conditions related to steroid metabolism.
Not a fit: Patients who are not on any medications or do not have conditions related to steroid metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of drug interactions and improve medication safety and efficacy for patients.
How similar studies have performed: Previous research has successfully identified the roles of other solute carrier transporters, suggesting that this approach may yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Giacomini, Kathleen M — University of California, San Francisco
- Study coordinator: Giacomini, Kathleen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.