Understanding how a specific protein helps repair DNA
Official title: Mechanism of homologous recombination driven by the intrinsically disordered domain of tumor suppressor PALB2
Funded at Saint Louis University · NIH-11080361 · Data updated 2026-11-12
This study is looking at a part of the PALB2 protein that helps fix DNA, which is important for people with certain genetic conditions, especially those with BRCA1 or BRCA2 mutations, to find new ways to improve DNA repair and develop better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $303,000 |
| NIH project number | 5R01GM154323-02 |
| Project ID | NIH-11080361 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with mutations in the BRCA1 or BRCA2 genes, as they are at higher risk for breast and ovarian cancers.
✕Less likely to help
Patients without genetic predispositions to breast cancer or those not carrying BRCA mutations may not receive direct benefits from this research.
What this research studies
This research investigates the role of an unstructured region of the PALB2 protein in the process of homologous recombination, which is crucial for DNA repair. By examining how this intrinsically disordered domain interacts with DNA and other proteins, the research aims to uncover new mechanisms of DNA repair that could be applicable to various genetic conditions. Patients may benefit from insights gained about how DNA repair processes can be enhanced or targeted in therapies, especially for those with mutations in BRCA1 or BRCA2 genes. The study employs biochemical and biophysical techniques to analyze these interactions at a molecular level.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with breast cancer and other genetic disorders related to DNA repair.
How similar studies have gone: Similar research has shown promise in understanding the roles of intrinsically disordered proteins in DNA repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Korolev, Sergey — Saint Louis University
- Study coordinator: Korolev, Sergey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.