Understanding how a specific protein helps protect our DNA from damage caused by oxidative stress
Elucidating the Mitochondrial and Nuclear functions of ATP Synthase Subunit ATP5A1 that Maintain Genome Integrity in Response to Oxidative Stress
This study is looking at how a protein called ATP5A1 helps protect our DNA from damage caused by stress in our bodies, which can be important for understanding cancer and finding new treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10877013 on NIH RePORTER |
What this research studies
This research investigates the role of the ATP5A1 protein in maintaining the integrity of our DNA when faced with oxidative stress, which can lead to DNA damage. The study employs advanced techniques, including CRISPR/Cas9, to explore how ATP5A1 interacts with other proteins and responds to harmful reactive oxygen species. By examining these interactions, the research aims to uncover mechanisms that could improve our understanding of DNA damage responses and potential cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to oxidative stress or DNA damage, such as certain cancers.
Not a fit: Patients with conditions unrelated to oxidative stress or DNA integrity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting DNA from damage, potentially improving cancer treatment outcomes.
How similar studies have performed: Previous research has shown promising results in understanding DNA damage responses, but this specific approach using ATP5A1 is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Pfister, Neil Thomas — University of Alabama at Birmingham
- Study coordinator: Pfister, Neil Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.