Understanding how a specific protein helps prevent viral infections
Role of the integral membrane protease ZMPSTE24 in membrane protein biogenesis and virus-host cell fusion
This study is looking at a protein called ZMPSTE24 to see how it helps protect our cells from viruses by working with other small proteins, and the findings could lead to new treatments for viral infections that might help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11074692 on NIH RePORTER |
What this research studies
This research investigates the role of the ZMPSTE24 protein in the biogenesis of membrane proteins and its potential function in defending against viral infections. By studying how ZMPSTE24 interacts with small membrane proteins known as interferon-induced transmembrane proteins (IFITMs), the research aims to uncover mechanisms that block viruses from entering host cells. The approach involves detailed biophysical characterization and analysis of cellular pathways to understand how these proteins work together to enhance antiviral defenses. Patients may benefit from insights gained in this research that could lead to new antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals at risk for viral infections or those with conditions that compromise their immune response.
Not a fit: Patients with non-viral related health issues or those not affected by viral infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies that enhance the body's natural defenses against viral infections.
How similar studies have performed: Other research has shown promising results in understanding the role of membrane proteins in viral defense, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Michaelis, Susan D. — Johns Hopkins University
- Study coordinator: Michaelis, Susan D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.