Understanding how a specific protein helps immune cells develop and function
Official title: The BTB-ZF transcription factor, PLZF, requires YY1 to function
Funded at Rutgers Biomedical and Health Sciences · NIH-11109665 · Data updated 2026-11-12
This study is looking at how two proteins, PLZF and YY1, work together to help shape immune cells, especially a type called natural killer T (NKT) cells, which could lead to new ways to treat immune-related conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 6, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $196,250 |
| NIH project number | 5R21AI180563-02 |
| Project ID | NIH-11109665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with immune system disorders or those interested in the genetic basis of immune function.
✕Less likely to help
Patients with non-immune related conditions or those not affected by immune system dysfunction may not receive any benefit from this research.
What this research studies
This research investigates the role of the PLZF transcription factor in the development and function of immune cells, particularly focusing on its interaction with another protein called YY1. By examining how these proteins work together, the research aims to uncover critical mechanisms that influence the identity and function of immune cells, such as natural killer T (NKT) cells. The approach involves advanced techniques like ATAC sequencing to analyze chromatin accessibility, which helps in understanding gene regulation in these cells. Patients may benefit from insights gained about immune system development and potential therapeutic targets for immune-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating immune disorders by enhancing our understanding of immune cell development.
How similar studies have gone: Other research has shown success in understanding transcription factors in immune cell development, indicating that this approach is promising.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Sant'angelo, Derek B. — Rutgers Biomedical and Health Sciences
- Study coordinator: Sant'angelo, Derek B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.