Understanding how a specific protein helps heal dental pulp after injury
Official title: The novel functions of matrix metalloproteinase 13 supporting dentin-pulp reparative processes
Funded at Rutgers Biomedical and Health Sciences · NIH-11058693 · Data updated 2026-11-12
This study is looking at how a specific protein called MMP13 helps heal damaged tooth nerves after issues like cavities or injuries, with the goal of finding better treatments to help your teeth recover more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 5, 2024 |
| Project end | June 4, 2026 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 1R56DE033709-01 |
| Project ID | NIH-11058693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing dental pulp injuries due to caries or trauma.
✕Less likely to help
Patients with healthy dental pulp or those not experiencing pulpitis may not benefit from this research.
What this research studies
This research investigates the role of matrix metalloproteinase 13 (MMP13) in the healing processes of dental pulp tissues following injuries such as tooth decay or trauma. The study aims to uncover how MMP13 influences the formation of tertiary dentin and the immune response during acute pulpitis. By exploring these mechanisms, the research seeks to develop new biologically-based treatments that can improve vital pulp therapy and enhance the healing of damaged teeth. Patients may benefit from advancements in dental treatments that promote better recovery from pulp injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for dental pulp injuries, enhancing healing and preserving tooth vitality.
How similar studies have gone: Previous research has shown promising results in understanding the role of proteins in dental tissue repair, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Shimizu, Emi — Rutgers Biomedical and Health Sciences
- Study coordinator: Shimizu, Emi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.