Understanding how a specific protein helps fight monkeypox virus in the body
Official title: Characterization of a sensor domain for cytoplasmic nucleic acid in the antiviral factor, SAMD9
Funded at University of Texas Hlth Science Center · NIH-10999180 · Data updated 2026-11-12
This study is looking at a protein called SAMD9 to see how it helps our immune system fight off the monkeypox virus, especially in the mouth, and aims to find better ways to protect people from getting sick.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $38,314 |
| NIH project number | 1F31AI186499-01 |
| Project ID | NIH-10999180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of monkeypox infection, particularly those with oral exposure.
✕Less likely to help
Patients who are not at risk of monkeypox or those who have already been vaccinated against it may not benefit from this research.
What this research studies
This research investigates the role of a protein called SAMD9, which is important for the body's immune response against the monkeypox virus. The study focuses on how SAMD9 detects viral infections and helps prevent the virus from replicating in cells, particularly in the oral mucosa where the virus can cause significant pathology. By examining the mechanisms of SAMD9, researchers aim to develop better antiviral strategies to protect individuals from the effects of monkeypox. The research involves laboratory experiments to analyze the interactions between SAMD9 and the virus.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral treatments that reduce the severity of monkeypox infections and improve patient outcomes.
How similar studies have gone: Previous research on host restriction factors in viral infections has shown promise, indicating that understanding SAMD9 could lead to significant advancements in antiviral therapies.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Morales, Marisol — University of Texas Hlth Science Center
- Study coordinator: Morales, Marisol
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.