Understanding how a specific protein helps bacteria survive high levels of zinc
Official title: Determination of structure-function relationships and role in virulence of a MerR-type regulator that mediates zinc tolerance in Streptococcus mutans
Funded at University of Florida · NIH-10895964 · Data updated 2026-11-12
This study looks at a protein in the bacteria that causes cavities to see how it helps the bacteria survive in high levels of zinc, which can be harmful, and the findings could help us find better ways to prevent tooth decay.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 16, 2023 |
| Project end | August 15, 2025 |
| Funding year | 2024 |
| Award (this year) | $44,702 |
| NIH project number | 5F31DE032899-02 |
| Project ID | NIH-10895964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for dental caries, particularly those with a history of frequent cavities or poor oral health.
✕Less likely to help
Patients who do not have issues related to dental health or who are not at risk for caries may not benefit from this research.
What this research studies
This research investigates the role of a protein regulator in the bacteria Streptococcus mutans, which is known to contribute to dental caries. The study focuses on how this protein helps the bacteria tolerate high levels of zinc, which can be toxic in excess. By examining the structure and function of this protein, researchers aim to uncover new insights into bacterial behavior and its implications for oral health. Patients may benefit from findings that could lead to improved prevention strategies for dental decay.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing dental caries, potentially reducing the burden of this common disease.
How similar studies have gone: Previous research has shown that understanding bacterial tolerance mechanisms can lead to significant advancements in dental health treatments.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Peterson, Alexandra — University of Florida
- Study coordinator: Peterson, Alexandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.