Understanding how a specific protein helps bacteria build their swimming apparatus
Official title: Identification of the Role of FlgW in the Biogenesis of the fT3SS in Campylobacter jejuni
Funded at Ut Southwestern Medical Center · NIH-10996800 · Data updated 2026-11-12
This study is looking at a special protein called FlgW to understand how the Campylobacter jejuni bacteria build their flagella, which help them move and can make people sick, and it involves a team of experts to help uncover the details of this process.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $40,127 |
| NIH project number | 1F31AI186490-01 |
| Project ID | NIH-10996800 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals affected by infections caused by Campylobacter jejuni or related bacterial pathogens.
✕Less likely to help
Patients with infections caused by other types of bacteria that do not utilize the fT3SS mechanism may not benefit from this research.
What this research studies
This research investigates the role of a unique protein, FlgW, in the construction of the flagellar type III secretion system (fT3SS) in the bacterium Campylobacter jejuni. By employing structural, molecular, and biochemical techniques, the research aims to uncover the molecular mechanisms that enable this bacterium to assemble its flagella, which are crucial for its movement and ability to cause disease. The project will involve a mentoring team with expertise in various fields, ensuring a comprehensive approach to understanding this complex biological process.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by Campylobacter jejuni.
How similar studies have gone: While the specific focus on FlgW in Campylobacter jejuni is novel, similar research on flagellar biogenesis in other bacteria has shown promising results.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Dobbins, Amanda — Ut Southwestern Medical Center
- Study coordinator: Dobbins, Amanda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.