Understanding how a specific protein helps assemble mitochondrial ribosomes
Official title: Mechanisms for control of mitoribosome assembly by the GTPase ERAL1
Funded at Brandeis University · NIH-11138869 · Data updated 2026-11-12
This study is looking at how a protein called ERAL1 helps put together the tiny machines in our cells that make energy, which is especially important for people with certain genetic mutations that can lead to mitochondrial diseases.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $157,260 |
| NIH project number | 1R03TR005620-01 |
| Project ID | NIH-11138869 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations that affect mitochondrial function, particularly those with conditions like Perrault syndrome.
✕Less likely to help
Patients with mitochondrial dysfunction not related to ribosome assembly or those without genetic mutations may not benefit from this research.
What this research studies
This research investigates the role of the GTPase ERAL1 in the assembly of mitochondrial ribosomes, which are crucial for producing components of the electron transport chain. By studying how ERAL1 interacts with ribosomal RNA and protein subunits, the research aims to uncover the mechanisms behind mitoribosome assembly and the consequences of its dysfunction. Patients with certain genetic mutations affecting ribosome assembly may experience various mitochondrial diseases, and this research could provide insights into these conditions. The methodology includes biochemical assays and genetic analysis in model organisms to explore the assembly process.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for mitochondrial diseases linked to ribosome assembly dysfunction.
How similar studies have gone: While the specific role of ERAL1 in ribosome assembly is being explored, similar research has shown that understanding mitochondrial processes can lead to significant advancements in treating related diseases.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Kardon, Julia R. — Brandeis University
- Study coordinator: Kardon, Julia R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.