Understanding how a specific protein from orthopoxvirus affects immune response
Official title: Uncovering the molecular underpinnings of C15, a potent orthopoxvirus virulence factor
Funded at University of Pennsylvania · NIH-10900539 · Data updated 2026-11-12
This study is looking at a protein from a virus that can help it avoid the immune system, and by understanding how this protein works with certain immune cells, we hope to find new ways to treat infections caused by this virus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $36,803 |
| NIH project number | 1F31AI183694-01 |
| Project ID | NIH-10900539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of orthopoxvirus infections, including those with compromised immune systems or those living in areas experiencing outbreaks.
✕Less likely to help
Patients who are not at risk for orthopoxvirus infections or those who have already been vaccinated may not benefit from this research.
What this research studies
This research investigates the role of the C15 protein from orthopoxvirus, which is known to inhibit immune responses in infected individuals. By studying how C15 interacts with immune cells, particularly CD8 T cells and natural killer cells, the research aims to uncover the molecular mechanisms that contribute to the virus's ability to cause disease. The approach involves detailed biological assays and analysis of the protein's structure and function, which could lead to new strategies for treating infections caused by orthopoxviruses.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments and vaccines against orthopoxvirus infections.
How similar studies have gone: Previous research has shown promise in understanding viral proteins and their interactions with the immune system, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Carro, Stephen David — University of Pennsylvania
- Study coordinator: Carro, Stephen David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.