Understanding how a specific protein contributes to a serious condition related to inflammation.
Official title: Investigating the role of helix-1 in the fibrillization of SAA1-76
Funded at York College · NIH-10974667 · Data updated 2026-11-12
This study is looking at how a protein called serum amyloid A (SAA) changes in people with AA amyloidosis, a serious condition linked to long-term inflammation, to better understand how it causes damage and to help find new ways to treat it.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | York College NIH-funded |
| Lab location | 1 site (Jamaica, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $496,648 |
| NIH project number | 1R15GM155857-01 |
| Project ID | NIH-10974667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions that may lead to AA amyloidosis.
✕Less likely to help
Patients who do not have chronic inflammatory disorders or who are not at risk for AA amyloidosis may not benefit from this research.
What this research studies
This research investigates the role of a protein called serum amyloid A (SAA) in the development of AA amyloidosis, a severe condition that can result from chronic inflammation. The study focuses on how the structure of a specific part of the SAA protein, known as helix-1, changes and contributes to the formation of harmful amyloid fibrils. By creating and analyzing modified versions of this protein, researchers aim to uncover the mechanisms behind its misfolding and how it leads to organ damage. The findings could help in designing potential treatments to prevent or reduce the severity of this condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat AA amyloidosis, improving outcomes for patients with chronic inflammatory disorders.
How similar studies have gone: Previous research has shown promising results in understanding protein misfolding and its implications in amyloidosis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
York College
Jamaica, United States Active
Researchers
- Principal investigator: Desamero, Ruel Z B — York College
- Study coordinator: Desamero, Ruel Z B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.