Understanding how a specific protein complex affects bone growth disorders
Official title: ELUCIDATING THE ROLE OF COATOMER COMPLEX COPI IN SKELETAL DYSPLASIA
Funded at Baylor College of Medicine · NIH-11063112 · Data updated 2026-11-12
This study is looking into how a specific protein complex affects bone growth in people with skeletal dysplasia, and it's designed to help researchers like Dr. Ronit Marom learn more about this condition to find better treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $134,041 |
| NIH project number | 5K08HD108381-03 |
| Project ID | NIH-11063112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are children under 11 years old diagnosed with skeletal dysplasia or related bone growth disorders.
✕Less likely to help
Patients with skeletal dysplasia who are over the age of 11 or those with unrelated bone conditions may not receive direct benefits from this research.
What this research studies
This research focuses on the role of the coatomer complex COPI in skeletal dysplasia, a condition that affects bone development. The project aims to explore the molecular genetic basis of these disorders through a combination of laboratory techniques, including microscopy imaging and glycoproteomics. The principal investigator, Dr. Ronit Marom, is receiving mentorship and training to enhance their research skills, which will ultimately contribute to a better understanding of skeletal dysplasias and potential treatment avenues. The research will involve collaboration with an advisory committee to ensure comprehensive guidance and support.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for children with skeletal dysplasias.
How similar studies have gone: Previous research in the field of skeletal dysplasia has shown promise in understanding the genetic factors involved, indicating that this approach has potential for success.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Marom, Ronit — Baylor College of Medicine
- Study coordinator: Marom, Ronit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.