Understanding how a specific protein affects the structure and function of the nucleolus in cells.
Uncovering novel players in nucleolar organization and function
This study is looking at a protein called ZNF692 to understand how it helps keep a part of our cells, called the nucleolus, working properly, which is important for making ribosomes; the findings could help us learn more about diseases like Alzheimer's and cancer, potentially leading to better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11061863 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called ZNF692 in maintaining the structure and function of the nucleolus, a key cellular organelle involved in producing ribosomes. By studying how ZNF692 interacts with other proteins and influences ribosome biogenesis, the research aims to uncover the molecular mechanisms that could be disrupted in diseases like Alzheimer's and cancer. Patients may benefit from insights gained about nucleolar defects and their implications for neurodegenerative disorders and cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by nucleolar dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other neurodegenerative conditions by targeting nucleolar dysfunction.
How similar studies have performed: Previous studies have shown that targeting nucleolar defects can have therapeutic potential in cancer and neurodegenerative diseases, suggesting that this approach may yield promising results.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Conacci-Sorrell, Maralice — Ut Southwestern Medical Center
- Study coordinator: Conacci-Sorrell, Maralice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.