Understanding how a specific protein affects the growth of artificial blood vessels in heart surgery.
Elucidating the Molecular Mechanisms Underlying LYST-mediated Tissue Engineered Vascular Graft Stenosis
This study is looking at how a specific protein affects problems with artificial blood vessels used in heart surgery for kids, with the hope of finding ways to prevent narrowing of these vessels so they work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10808927 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind complications in tissue engineered vascular grafts (TEVGs) used in congenital heart surgery. It focuses on a protein encoded by the LYST gene, which has been found to influence the occurrence of stenosis, a common complication that limits the use of these grafts. By studying genetically modified mouse models, researchers aim to identify the cellular processes and immune responses that lead to this complication. The ultimate goal is to develop strategies to prevent stenosis, enhancing the effectiveness of TEVGs for patients requiring heart surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart defects who may require surgical interventions involving tissue engineered vascular grafts.
Not a fit: Patients without congenital heart defects or those not requiring vascular grafts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for patients undergoing congenital heart surgery by reducing complications associated with artificial blood vessels.
How similar studies have performed: Previous research has shown promise in understanding the role of immune responses in graft complications, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Breuer, Christopher Kane — Research Inst Nationwide Children's Hosp
- Study coordinator: Breuer, Christopher Kane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.