Understanding how a specific protein affects the fusion of bone cells
A critical role for PLD1 in osteoclast fusion
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10670234
This study is looking at how a specific protein called PLD1 helps bone-resorbing cells called osteoclasts come together, with the goal of finding new ways to treat bone loss conditions like osteoporosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10670234 on ClinicalTrials.gov |
What this research studies
This research investigates the role of phospholipase D1 (PLD1) in the fusion of osteoclasts, which are cells responsible for bone resorption. By examining how PLD1 influences the formation of these cells, the study aims to uncover new therapeutic strategies for conditions like osteoporosis, where bone loss occurs due to imbalanced remodeling. The researchers will conduct in vitro experiments to explore the molecular mechanisms behind osteoclast fusion and how targeting PLD1 could improve treatment outcomes for patients with bone diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from osteoporosis or other conditions that lead to excessive bone resorption.
Not a fit: Patients with bone diseases not related to osteoclast function or those who do not have osteoporosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for osteoporosis and other bone disorders by targeting the fusion process of osteoclasts.
How similar studies have performed: Previous research has shown promise in targeting cellular mechanisms for bone health, suggesting that this approach could yield significant advancements.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DU, GUANGWEI — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: DU, GUANGWEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Diseases, bone disorder, Cancers