Understanding how a specific protein affects the development of the palate
Deciphering a tissue specific role for Arhgap29 during palatogenesis
This study is looking at how a protein called ARHGAP29 affects the development of the mouth and face, especially in babies born with clefts, to find better ways to treat these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11047544 on NIH RePORTER |
What this research studies
This research investigates the role of the ARHGAP29 protein in the development of the palate, particularly focusing on orofacial clefts, which are common birth defects. By studying genetic and environmental factors that influence palatogenesis, the research aims to identify molecular pathways that could lead to improved treatment options. The approach includes using animal models to observe the effects of ARHGAP29 on craniofacial development and understanding how its absence can lead to developmental issues. This comprehensive understanding could pave the way for better clinical interventions for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with orofacial clefts or those with a family history of such conditions.
Not a fit: Patients without orofacial clefts or related craniofacial abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to enhanced treatment options for children born with orofacial clefts.
How similar studies have performed: Previous research has shown success in understanding genetic factors related to orofacial clefts, making this approach promising.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Adelizzi, Emily — University of Iowa
- Study coordinator: Adelizzi, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.