Understanding how a specific protein affects the development of B cells in the immune system
YY1-dependent chromatin structure stabilization of B lineage commitment
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10886707
This study is looking at a protein called YY1 to see how it helps B cells, which are important for fighting infections, develop properly; by understanding this process better, the researchers hope to find new ways to help people with immune system disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10886707 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the YY1 protein in the commitment of B cells, which are crucial for the immune response. By examining how the absence of YY1 affects gene expression and chromatin structure during the transition from pre-pro-B to pro-B cells, the study aims to uncover the mechanisms that stabilize B cell lineage commitment. The researchers will use advanced techniques to analyze gene interactions and chromatin changes, providing insights into how B cells develop and function. This could lead to a better understanding of immune system disorders and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to B cell dysfunction or immune system disorders.
Not a fit: Patients with conditions unrelated to B cell development or those who do not have immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating immune-related diseases by enhancing our understanding of B cell development.
How similar studies have performed: Previous research has shown that understanding transcription factors and chromatin dynamics can lead to significant advancements in immunology, suggesting that this approach has potential for success.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ATCHISON, MICHAEL LEE — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: ATCHISON, MICHAEL LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.