Understanding how a specific protein affects social memory and cognition.
Dissecting the roles of an epigenetic regulator of genes involved in synaptic plasticity and social cognition.
['FUNDING_R01'] · UPSTATE MEDICAL UNIVERSITY · NIH-11007231
This study is looking at how a protein called PHF21B affects social memory, especially in people with conditions like autism and ADHD, using animal models to understand how its absence might lead to difficulties in social interactions and memory.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UPSTATE MEDICAL UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-11007231 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the PHF21B protein in social memory, particularly how its deficiency can lead to social cognitive impairments seen in conditions like autism spectrum disorder and attention deficit hyperactivity disorder. The study uses animal models to explore the mechanisms behind these impairments, employing tests that measure social interaction and memory. By examining the relationship between PHF21B and epigenetic markers, the research aims to uncover potential pathways that could be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or attention deficit hyperactivity disorder, as well as those who have experienced acute brain injuries.
Not a fit: Patients with social cognitive impairments not related to the mechanisms being studied, or those without a diagnosis of the targeted conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for social cognitive impairments in various psychiatric and neurodevelopmental disorders.
How similar studies have performed: Other research has shown promising results in understanding the genetic and epigenetic factors influencing social cognition, suggesting that this approach could yield valuable insights.
Where this research is happening
SYRACUSE, UNITED STATES
- UPSTATE MEDICAL UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WONG, MA-LI — UPSTATE MEDICAL UNIVERSITY
- Study coordinator: WONG, MA-LI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Attention deficit hyperactivity disorder