Understanding how a specific protein affects obesity development
Official title: Intestinal Intelectin-1 regulation of obesity development
Funded at Children's Hosp of Philadelphia · NIH-11085285 · Data updated 2026-11-12
This study is looking at how a protein called Intelectin-1 in the gut affects the balance of gut bacteria and how this might influence weight gain and obesity in babies, with the goal of finding ways to help prevent obesity from an early age.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $158,976 |
| NIH project number | 5K08DK133639-04 |
| Project ID | NIH-11085285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in understanding the early life factors contributing to obesity, particularly those with a family history of obesity or metabolic disorders.
✕Less likely to help
Patients who are not in the age range of 21 years and older or those without concerns related to obesity may not benefit from this research.
What this research studies
This research investigates the role of intestinal Intelectin-1 (ITLN1) in the function and composition of gut microbes and its impact on obesity and weight gain during early life. The project aims to explore how interactions between the host and microbiota can influence obesity risk, particularly starting from the neonatal period. By employing multidisciplinary approaches, the research seeks to develop preventative strategies against obesity. The team includes experts in microbiology, immunology, and metabolism, ensuring a comprehensive approach to the problem.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing obesity from an early age.
How similar studies have gone: Other research has shown promising results in understanding the microbiota's role in obesity, indicating that this approach has potential for success.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Matute, Juan D. — Children's Hosp of Philadelphia
- Study coordinator: Matute, Juan D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.