Understanding how a specific protein affects lung injury
Role of intravascular ERO1@ in acute lung injury
This study is looking at how a protein called ERO1α affects lung injuries by exploring how it influences white blood cells and lung cells during inflammation, with the hope of finding new ways to help people who are struggling with this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10686908 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called ERO1α in acute lung injury (ALI), a serious condition affecting many patients each year. The study focuses on how ERO1α influences the interactions between neutrophils, a type of white blood cell, and the cells lining blood vessels in the lungs. By using advanced imaging techniques, researchers aim to uncover the mechanisms that lead to excessive neutrophil recruitment during lung inflammation, which is a key factor in ALI. The ultimate goal is to identify potential therapeutic targets that could improve treatment outcomes for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing acute lung injury due to conditions like pneumonia, sepsis, or trauma.
Not a fit: Patients with chronic lung conditions or those not experiencing acute lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung inflammation and improve recovery for patients with acute lung injury.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar proteins in inflammatory processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cho, Jaehyung — Washington University
- Study coordinator: Cho, Jaehyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.