Understanding how a specific protein affects liver disease
Official title: Regulation and Function of Thioredoxin Interacting Protein (Txnip) in Nonalcoholic Steatohepatitis (NASH)
Funded at Temple Univ of the Commonwealth · NIH-11085102 · Data updated 2026-11-12
This study is looking at a protein called Txnip to see how it affects liver health in people with nonalcoholic steatohepatitis (NASH), and it aims to create a new treatment that could help improve liver function for those dealing with this tough condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $348,700 |
| NIH project number | 5R01DK134494-03 |
| Project ID | NIH-11085102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with nonalcoholic steatohepatitis (NASH) who have not responded to existing treatments.
✕Less likely to help
Patients with other forms of liver disease unrelated to NASH may not benefit from this research.
What this research studies
This research investigates the role of Thioredoxin Interacting Protein (Txnip) in nonalcoholic steatohepatitis (NASH), a severe form of liver disease with limited treatment options. The study aims to develop a new therapeutic approach by creating a Txnip inhibitor that targets its function specifically in the liver. Researchers will explore how Txnip contributes to liver cell death, which is a key factor in the progression of NASH. By focusing on the liver-specific effects of Txnip, the research seeks to provide insights that could lead to effective treatments for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to a novel therapy for patients with nonalcoholic steatohepatitis, potentially improving liver health and patient outcomes.
How similar studies have gone: While the role of Txnip in liver disease is being explored, this specific approach using a Txnip inhibitor is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Yang, Ling — Temple Univ of the Commonwealth
- Study coordinator: Yang, Ling
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.