Understanding how a specific protein affects kidney gene expression and diseases.
Official title: Regulation of Kidney-Specific Gene Expression
Funded at State University New York Stony Brook · NIH-10884168 · Data updated 2026-11-12
This study is looking at how a protein called HNF-1β affects kidney function and may play a role in kidney diseases like cystic kidney disease, using specially modified mice to help understand these processes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | November 18, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $461,046 |
| NIH project number | 5R01DK042921-34 |
| Project ID | NIH-10884168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital kidney anomalies, cystic kidney disease, or other inherited kidney disorders.
✕Less likely to help
Patients with non-genetic kidney diseases or those without a family history of kidney disorders may not benefit from this research.
What this research studies
This research investigates the role of hepatocyte nuclear factor-1β (HNF-1β) in regulating gene expression specific to the kidneys and its implications for cystic kidney diseases. By studying genetically modified mice that mimic human kidney disorders, researchers aim to uncover the mechanisms by which HNF-1β influences kidney function and disease progression. The project employs advanced techniques like ChIP-seq and RNA-seq to analyze how HNF-1β interacts with other proteins and regulates various signaling pathways in the kidneys.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for patients with genetic kidney diseases.
How similar studies have gone: Previous research has shown promising results in understanding kidney diseases through similar genetic and molecular approaches.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Igarashi, Peter — State University New York Stony Brook
- Study coordinator: Igarashi, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.