Understanding how a specific protein affects kidney cyst growth in a genetic kidney disease.
Official title: Mechanisms of cyst progression driven by Na,K-ATPase in autosomal dominant polycystic kidney disease (ADPKD).
Funded at University of Kansas Medical Center · NIH-10902964 · Data updated 2026-11-12
This study is looking at how a protein in your kidneys affects the growth of cysts in people with autosomal dominant polycystic kidney disease (ADPKD) and how a compound called ouabain might make those cysts grow faster, with the hope of finding new ways to slow down the disease and help patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 4, 2024 |
| Project end | August 3, 2028 |
| Funding year | 2024 |
| Award (this year) | $37,313 |
| NIH project number | 1F30DK137438-01A1 |
| Project ID | NIH-10902964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with autosomal dominant polycystic kidney disease.
✕Less likely to help
Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the Na,K-ATPase protein influences the progression of cysts in patients with autosomal dominant polycystic kidney disease (ADPKD). The study focuses on how a compound called ouabain affects kidney cells, promoting cyst growth by increasing cell proliferation and altering fluid secretion. By examining these processes in both human kidney cells and animal models, the research aims to uncover potential therapeutic targets for slowing down disease progression. Patients may benefit from insights that could lead to new treatment strategies for managing ADPKD.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow the progression of kidney cysts in patients with ADPKD.
How similar studies have gone: Previous research has shown promising results in understanding the role of Na,K-ATPase in kidney diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Trant, Jordan — University of Kansas Medical Center
- Study coordinator: Trant, Jordan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.