Understanding how a specific protein affects kidney cyst growth
Official title: CDKN1A (p21) regulation of cyst growth
Funded at University of Alabama at Birmingham · NIH-11022749 · Data updated 2026-11-12
This study is looking at how a specific protein affects the growth of kidney cysts that can happen when certain genes don’t work properly, especially after kidney injuries, and it hopes to find new ways to help people with kidney cyst issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $587,212 |
| NIH project number | 1R01DK141552-01 |
| Project ID | NIH-11022749 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting cilia function, particularly those at risk for renal cyst formation.
✕Less likely to help
Patients without genetic predispositions to kidney cysts or those with unrelated kidney conditions may not benefit from this research.
What this research studies
This research investigates the role of the CDKN1A (p21) protein in the formation of kidney cysts caused by mutations in cilia function. It explores how the absence of certain genes leads to cyst initiation and how injury to the kidney accelerates this process. By analyzing gene expression in kidney cells, the study aims to uncover the mechanisms behind cyst growth and the potential for maladaptive repair in injured tissues. Patients may benefit from insights into new treatment strategies for kidney cyst-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for preventing or treating kidney cysts.
How similar studies have gone: Previous research has shown promising results in understanding the role of polycystins in kidney disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Yoder, Bradley K. — University of Alabama at Birmingham
- Study coordinator: Yoder, Bradley K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.