Understanding how a specific protein affects kidney cyst formation in a genetic disease.
Official title: Unraveling the Ciliary Driver of Polycystic Kidney Disease
Funded at Emory University · NIH-10949899 · Data updated 2026-11-12
This study is looking at how a protein called ARL13B might play a role in the development of kidney cysts in people with polycystic kidney disease (PKD), using a special mouse model to better understand how it works and how it interacts with other proteins.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $142,902 |
| NIH project number | 1K01DK140605-01 |
| Project ID | NIH-10949899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with polycystic kidney disease.
✕Less likely to help
Patients with kidney diseases unrelated to polycystic kidney disease may not benefit from this research.
What this research studies
This research focuses on polycystic kidney disease (PKD), a genetic condition that leads to kidney failure. The study aims to investigate the role of a protein called ARL13B, which is located in a cellular structure known as the primary cilium, in the development of kidney cysts. By using a novel genetic mouse model, the researchers will explore how ARL13B interacts with other proteins that may contribute to cyst formation. This work involves biochemical and genetic techniques to identify critical interactions and mechanisms involved in the disease process.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for patients suffering from polycystic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of ciliary proteins in kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Van Sciver, Robert E — Emory University
- Study coordinator: Van Sciver, Robert E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.