Understanding how a specific protein affects insulin secretion in diabetes
Official title: A novel role for 14-3-3-ζ in regulating islet cell crosstalk
Funded at University of California at Davis · NIH-10998351 · Data updated 2026-11-12
This study is looking at a protein called 14-3-3-ζ to see how it helps the cells in your pancreas communicate with each other, which is important for insulin production, especially for people with type 2 diabetes, to find new ways to improve insulin release and blood sugar control.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | July 15, 2024 |
| Project end | July 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,972 |
| NIH project number | 1F31DK139734-01A1 |
| Project ID | NIH-10998351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who may benefit from improved insulin regulation.
✕Less likely to help
Patients with type 1 diabetes or those without any form of diabetes may not receive benefits from this research.
What this research studies
This research investigates the role of the protein 14-3-3-ζ in regulating communication between pancreatic islet cells, which are crucial for insulin secretion. The study focuses on how this protein influences the function of alpha and beta cells in the pancreas, particularly in the context of type 2 diabetes mellitus. By examining the mechanisms that preserve islet function, the research aims to identify potential therapeutic targets that could enhance insulin secretion and improve glucose regulation. The approach includes both in vitro studies using human and mouse islets to observe the effects of manipulating 14-3-3-ζ levels.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin secretion and glucose control for patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding islet cell communication and its impact on diabetes management, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Shishani, Rahaf — University of California at Davis
- Study coordinator: Shishani, Rahaf
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.