Understanding how a specific protein affects infertility in women with endometriosis
Epigenetic regulation of receptive endometrium
['FUNDING_R01'] · UNIVERSITY OF MISSOURI-COLUMBIA · NIH-11009910
This study is looking at how a protein called HDAC3 in the uterus might be linked to infertility in women with endometriosis, and it hopes to find new ways to help improve pregnancy chances for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSOURI-COLUMBIA (nih funded) |
| Locations | 1 site (COLUMBIA, UNITED STATES) |
| Trial ID | NIH-11009910 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called HDAC3 in the uterus and its connection to infertility, particularly in women suffering from endometriosis. By using animal models, the study aims to uncover how the loss of HDAC3 affects the ability of the uterus to support pregnancy. The researchers will explore the mechanisms behind implantation defects and how hormonal signals are regulated in the endometrium. The ultimate goal is to provide insights that could lead to new treatments for infertility and endometrial diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who are experiencing infertility, particularly those diagnosed with endometriosis.
Not a fit: Patients who are not experiencing infertility or do not have endometriosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve fertility for women with endometriosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic factors in infertility, suggesting that this approach could yield valuable insights.
Where this research is happening
COLUMBIA, UNITED STATES
- UNIVERSITY OF MISSOURI-COLUMBIA — COLUMBIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JEONG, JAE-WOOK — UNIVERSITY OF MISSOURI-COLUMBIA
- Study coordinator: JEONG, JAE-WOOK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.