Understanding how a specific protein affects immune responses in the gut during inflammatory bowel disease.
Integrin αEβ7-dependent IgA transcytosis during homeostasis and IBD
This study is looking at how a specific protein helps immune cells deliver an important antibody to the gut, which is especially important for people with inflammatory bowel disease (IBD), and it hopes to find new ways to improve gut health for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10786123 on NIH RePORTER |
What this research studies
This research investigates the role of integrin αEβ7 in the immune system's response to the gut microbiota, particularly in patients with inflammatory bowel disease (IBD). It focuses on how certain immune cells, specifically plasma cells, use this integrin to transport immunoglobulin A (IgA) to the intestine, which is crucial for maintaining a healthy gut environment. By studying mouse models and human samples, the research aims to uncover the mechanisms behind IgA production and its impact on gut health, potentially leading to new treatment strategies for IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with inflammatory bowel disease, particularly those who may not be responding well to current treatments.
Not a fit: Patients without inflammatory bowel disease or those with other unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from inflammatory bowel disease by enhancing our understanding of immune regulation in the gut.
How similar studies have performed: Previous research has shown success in targeting integrins for IBD treatment, suggesting that this approach may yield valuable insights and advancements.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Rivera-Nieves, Jesus — University of California, San Diego
- Study coordinator: Rivera-Nieves, Jesus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.